{"id":127913,"date":"2017-07-27T09:24:01","date_gmt":"2017-07-27T13:24:01","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=127913"},"modified":"2017-07-27T10:13:57","modified_gmt":"2017-07-27T14:13:57","slug":"new-imaging-test-can-detect-future-heart-problems-cancer-patients","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2017\/07\/new-imaging-test-can-detect-future-heart-problems-cancer-patients\/","title":{"rendered":"New Imaging Test Can Detect Future Heart Problems in Cancer Patients"},"content":{"rendered":"<p>UConn Health has begun tracking cancer patients with an advanced heart imaging test before, during, and after chemotherapy and radiation therapy care, with the goal of detecting any potential cardiac health risks or conditions early.<\/p>\n<p>There are currently more than 15 million cancer survivors in the U.S., and that number is expected to grow to 20 million within 10 years. But as more patients survive cancer, the potential risk of developing cardiovascular health issues from lifesaving chemotherapy and radiation treatments is also increasing.<\/p>\n<p>New echocardiography strain imaging is now allowing cardiologists to hunt for any early warning signs of heart muscle function changes or damage within the heart tissue\u2019s tiny speckles. The in-depth strain analysis is powered by traditional ultrasound technology, which uses high-frequency soundwaves to create a sonogram of the pumping heart.<\/p>\n<blockquote>\n  <p>Echo strain imaging has been compared to a canary in the coal mine. <cite> &#8212 Dr. Agnes Kim<\/cite><\/p>\n<\/blockquote>\n<p>On a subclinical level, before any symptoms even present, echo strain imaging allows a cardiologist to identify any potential impact of cancer treatment on the heart\u2019s left ventricular function, the thickest heart chamber, that controls the pumping of oxygenated blood throughout the body. If the left ventricle does not function well, it can lead to heart failure.<\/p>\n<p><a href=\"http:\/\/facultydirectory.uchc.edu\/profile?profileId=Kim-Agnes\">Dr. Agnes Kim<\/a>, director of the Cardio-Oncology Program at the Calhoun Cardiology Center at UConn Health, says it\u2019s very important to monitor cancer care patients for any signs of cardiac toxicity. \u201cEcho strain imaging has been compared to a canary in the coal mine,\u201d she says. \u201cWe are so grateful that our cancer patients have access to this latest technology so that we can monitor and intervene early on if any warning signs are present.\u201d<\/p>\n<p>The risk of cancer care side effects showing up during treatment or years down the road is a big concern of cardio-oncology specialists like Kim. That\u2019s why she launched the program in 2014.<\/p>\n<p>Kim says it is key that UConn Health has an integrated program of oncologists and cardiologists, which allows for coordinated care to address the potential risks to heart health that can arise from cancer treatment.<\/p>\n<aside class=\"grey-sidebar full-sidebar\">\n  <\/p>\n<h3><strong>Safeguarding the Heart of a Breast Cancer Patient<\/strong><\/h3>\n<p><figure id=\"attachment_127986\" aria-describedby=\"caption-attachment-127986\" style=\"width: 640px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped.jpg\"><img decoding=\"async\" class=\"size-large wp-image-127986 img-responsive lazyload\" data-src=\"https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped-1024x683.jpg\" alt=\"Dr. Agnes Kim and Karen Zucker. (Lauren Woods\/UConn Health Photo)\" width=\"640\" height=\"427\" data-srcset=\"https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped-1024x683.jpg 1024w, https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped-300x200.jpg 300w, https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped-768x512.jpg 768w, https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped-630x420.jpg 630w, https:\/\/today.uconn.edu\/wp-content\/uploads\/2017\/07\/DrKimandKarenZucker_cropped-150x100.jpg 150w\" data-sizes=\"(max-width: 640px) 100vw, 640px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 640px; --smush-placeholder-aspect-ratio: 640\/427;\" \/><\/a><figcaption id=\"caption-attachment-127986\" class=\"wp-caption-text\">Dr. Agnes Kim and patient Karen Zucker. (Lauren Woods\/UConn Health Photo)<\/figcaption><\/figure><\/p>\n<p>Karen Zucker, 53, of Newington has worked for decades in biomedical research. But even she had no idea that the chemotherapy saving her life from breast cancer could actually be harmful to her heart.<\/p>\n<p>To safeguard her heart health, the UConn Health oncology team of Drs. Susan Tannenbaum and Karen Hook made sure that cardiologist Dr. Agnes Kim of the Cardio-Oncology Program screened and closely monitored Zucker for any heart issues before and during chemotherapy.<\/p>\n<p>To closely monitor and track any abnormal changes within Zucker\u2019s heart muscle and its pumping function, Kim used the latest advanced imaging tool, called echocardiography strain imaging. The technology allows cardiologists to see on a subclinical level, before any heart symptoms present, if a patient is at risk of developing cardiotoxicity from chemotherapy medications or radiation.<\/p>\n<p>Zucker&#8217;s heart imaging test caught a decline in her heart\u2019s function and its ejection fraction \u2013 the percentage of blood leaving her heart on each contraction \u00a0\u2013 \u00a0resulting from her chemotherapy, a warning sign of the early development of heart failure.<\/p>\n<p>Kim told her it was very important to address this decrease in heart function promptly and not to wait, so that her heart function could be restored.\u00a0She\u00a0placed Zucker on two medications (a beta blocker and an ACE inhibitor) to reduce the adverse effects of chemotherapy on her heart, and as a result, her heart function has returned to near normal.<\/p>\n<p>\u201cMy heart is stronger now,\u201d says Zucker, who is determined to stay active to keep her heart healthy with gentle cardio exercises and aqua therapy three times a week.<\/p>\n<p>\u201cI am very pleased that my oncology team at UConn Health were proactive about protecting my heart health,\u201d she says. \u201cAll oncologists should be advising and monitoring their patients on the potential heart health risks from cancer treatment. And cancer patients need to be proactive as well, by asking their physicians about it.\u201d<\/p>\n<p>Radiation therapy as a teenager for Hodgkin\u2019s lymphoma had placed Zucker at higher risk of developing breast cancer. In Nov. 2015, she was diagnosed with cancer in her right breast following her annual mammogram, then her pathology results showed\u00a0that the cancer was present in both breasts. She had successful surgery with\u00a0UConn Health surgeon Dr. Peter Deckers, and in March 2016, she completed anthracycline chemotherapy.<\/aside>\n<p>Research studies have shown that confirming any changes in heart muscle strain can help doctors predict whether a patient is at risk for cardiotoxicity and its side effect of developing heart failure in the future. If a patient is found to have a 15 percent or more decline in heart strain, it is suggestive of cardiotoxicity, and doctors may prescribe cardio-protective drugs, such as a beta-blocker or ACE inhibitor, or modify the patient\u2019s chemotherapy dosage.<\/p>\n<p>Possible cardiotoxicity side effects from chemotherapy medications include a lowering of overall heart muscle function, which can lead to heart failure, formation of blood clots, or an increase in blood pressure. The side effects of radiation therapy can also lead to damaged heart muscle, heart valves, and arteries, or impact the lining of the heart.<\/p>\n<p>In hopes of gaining further insights, this program is currently studying the use of echo strain imaging, and also the presence of serum biomarkers in the blood for predicting whether a cancer patient is at high risk for cardiotoxicity. The program is also tracking cancer patients\u2019 long-term heart health, to analyze the impact of additional clinical care protections.<\/p>\n<p>Patients receiving such chemotherapies as doxorubicin (Adriamycin), trastuzumab (Herceptin), bevacizumab (Avastin), and 5-FU may be more at risk for cardiotoxicity. The majority of these chemotherapies are used to treat breast, gastrointestinal, and lymphoma or leukemia cancer patients.<\/p>\n<p>Kim says every cancer patient should talk to their oncologist about the potential side effects of their cancer treatment plan and how to reduce any heart health risks during and after cancer care.<\/p>\n<p><em>To learn more about the Cardio-Oncology Program at UConn Health, visit <\/em><a href=\"https:\/\/health.uconn.edu\/cardiology\"><em>this website<\/em><\/a><em> or call: 860-679-3343.<\/em><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>UConn Health has begun tracking cancer patients with an advanced heart imaging test before, during, and after treatment, to detect potential heart problems early.<\/p>\n","protected":false},"author":98,"featured_media":127987,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_crdt_document":"","wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[2231,179],"tags":[],"magazine-issues":[],"coauthors":[1873],"class_list":["post-127913","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-well-being","category-uconn-health"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-17 06:16:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/127913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/98"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=127913"}],"version-history":[{"count":9,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/127913\/revisions"}],"predecessor-version":[{"id":128002,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/127913\/revisions\/128002"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/127987"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=127913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=127913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=127913"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=127913"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=127913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}