{"id":165486,"date":"2020-10-21T17:38:41","date_gmt":"2020-10-21T21:38:41","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=165486"},"modified":"2021-04-13T16:32:59","modified_gmt":"2021-04-13T20:32:59","slug":"breakthrough-treatment-thyroid-eye-disease","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2020\/10\/breakthrough-treatment-thyroid-eye-disease\/","title":{"rendered":"Breakthrough Treatment for Thyroid Eye Disease"},"content":{"rendered":"

For those with severe inflammation from thyroid eye disease, the treatment options historically are limited and often require surgical removal of some of the bones or fat in the eye socket.<\/p>\n

That is, until earlier this year, when a new medication became available.<\/p>\n

Graves\u2019 disease is an autoimmune disorder that is the most common cause of overproduction of thyroid hormone, or hyperthyroidism. Nearly half of those with Graves\u2019 disease develop some form of what\u2019s known as thyroid eye disease. Inflammation and tissue enlargement in the orbits, or eye sockets, can cause the eyes to protrude or push forward, double vision, and swelling and compression stress on the optic nerve. In severe cases it can lead to vision loss.<\/p>\n

\"Dr.
Dr. Madina Falcone is an ophthalmologist specializing in oculoplastics and orbital surgery at UConn Health. (Photo by Tina Encarnacion)<\/figcaption><\/figure>\n

Dr. Madina Falcone<\/a>, an oculoplastics and orbital reconstructive surgeon at UConn Health, says thyroid eye disease\u2019s manner of development is complex and not completely understood.<\/p>\n

\u201cIt appears that in patients with hyperthyroidism, an elevated level of thyroid auto antibodies stimulates an inflammatory cascade within the orbit,\u201d Falcone says. \u201cThis in turn, through a series of complex steps, precipitates expansion of the muscles and the fat around the eye.\u201d<\/p>\n

At UConn Health, a team of physicians offers the only Food and Drug Administration-approved treatment for thyroid eye disease. Falcone works with UConn Health endocrinologists, internal medicine providers, and otolaryngologists (ear, nose and throat specialists) to offer proper management and care of the complex thyroid disease patient.<\/p>\n

The FDA approved the first drug for the treatment of thyroid eye disease, teprotumumab, earlier this year, sold under the trade name Tepezza.<\/p>\n

\u201cSimply put, Tepezza binds to specialized receptors in the tissues of the eye socket and blocks them, thereby decreasing the inflammation in the orbit,\u201d Falcone says.<\/p>\n

Teprotumumab is administered by intravenous infusion every three weeks for 24 weeks. It has shown in clinical trials to continue to be effective for a year after the therapy. Before it became available, the options to treat potentially vision-threatening thyroid eye disease were limited to a series of complex steps involving multiple specialties.<\/p>\n

\u201cYou would treat patients with oral or IV steroids and offer them orbital decompression surgery, where the bones of the orbit are removed in order to make more space for the tissue within the orbit and relieve the pressure within the compartment,\u201d Falcone says. \u201cAfter orbital surgery, I would evaluate the patient continuously and offer them surgery for realigning the eyes if needed, and then I would offer them eyelid surgery to reposition the eyelids if needed.\u201d<\/p>\n

The conditions aren\u2019t always right for teprotumumab, as it takes time for the drug to work, and the insurance approval process could take several weeks. Dire cases don\u2019t have that kind of time.<\/p>\n

\u201cIf somebody is actively losing vision because of their thyroid disease, they\u2019re receiving IV steroid infusions or oral steroids to help calm down the inflammation, and they\u2019re going to be operated on within a week,\u201d Falcone says. \u201cI\u2019m trying to get them into the OR immediately because I want to try to give them some chance of not going blind.\u201d<\/p>\n

The clinical trials studying teprotumumab evaluated patients diagnosed with thyroid eye diseases within six months of starting the regimen of infusions. However, given the impressive results of the treatment, qualifying patients are being enrolled to receive teprotumumab even if they are outside of the six-month window, potentially sparing them from more invasive interventions.<\/p>\n

Learn more about <\/em>ophthalmology<\/em><\/a>, <\/em>endocrinology<\/em><\/a>, and <\/em>otolaryngology<\/em><\/a> services at UConn Health. To arrange a consultation with Dr. Madina Falcone, call 860-679-3540.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

UConn Health offers the first and only FDA-approved thyroid infusion, which can delay or reduce the need for orbital surgery to relieve inflammation and preserve vision.<\/p>\n","protected":false},"author":111,"featured_media":165490,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_crdt_document":"","wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[1868,2294,179],"tags":[],"magazine-issues":[],"coauthors":[2010],"class_list":["post-165486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-meds","category-all-surgery","category-uconn-health"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-10 13:48:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/165486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/111"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=165486"}],"version-history":[{"count":2,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/165486\/revisions"}],"predecessor-version":[{"id":165492,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/165486\/revisions\/165492"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/165490"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=165486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=165486"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=165486"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=165486"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=165486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}