For the NSF-funded study, she seeks to develop a scaffold th Osteoarthritis is the top cause of chronic disability in the U.S., costing billions of dollars every year and incalculable pain for millions of people.\u00a0 Imagine how the future would change for sufferers if they were able to undergo a procedure that would reverse the progression of osteoarthritis and let them reclaim their quality of life.\u00a0 This is essentially what Dr. Wei is attempting to do.\u00a0 \u201cDamage to the articular cartilage surface and the underlying bone can easily progress to joint degeneration, especially osteoarthritis,\u201d Dr. Wei explains.<\/p>\n To relieve the effects of osteoarthritis, the damage to the articular cartilage must be reversed.\u00a0 \u201cExtensive efforts have been made in osteochondral [cartilage] defect treatment, but there is still no widely accepted method which produces consistent satisfactory results,\u201d she says.\u00a0 All previous attempts at repairing or regenerating the cartilage have produced a replacement inferior to articular cartilage. \u201cThe goal of this NSF project is to use a combination of a novel scaffold and an optimal cell source to effectively regenerate osteochondral cartilage with excellent functionality and long-term stability.\u201d<\/p>\n Biological scaffolds are artificial structures that can provide stability to regenerating tissue, making it easier for the cells to proliferate and develop.\u00a0 Dr. Wei is seeking to develop a graded scaffold that imitates the structure and properties of the articular cartilage and surrounding bone.\u00a0 The scaffold could be placed around a joint, providing temporary support.\u00a0 This would then be seeded with chondroprogenitor cells, which are cells that can develop into cartilage.\u00a0 As the cartilage develops, the support and protection to joints will be enhanced, mitigating the causes of osteoarthritis. Dr. Wei\u2019s imaging project focuses on developing means to watch the progress of bone repair procedures.\u00a0 As with cartilage regeneration, in bone repair a scaffold is seeded with the proper donor progenitor cells and placed at the site of the injury, facilitating regeneration.\u00a0 To evaluate and analyze a certain repair technique, researchers would find it helpful to determine how the different components involved in repair, namely the scaffold and the different cells, are interacting.\u00a0 Current imaging platforms, however, do not allow real-time imaging of cell-cell or cell-scaffold interactions in living animals. \u00a0To overcome this problem, Dr. Wei and her team will be working with a transgenic mouse model to test a four-dimensional imaging technique that will be able to track the progression of different bone repair techniques.\u00a0 This technique takes advantage of the fact that every cell lineage shows a different color at different stages of development.\u00a0 Dr. Rowe will create transgenic mice in which a specific reporter protein is expressed when cells differentiate into certain stage.\u00a0 These reporter proteins, called Green Fluorescent Proteins (GFP), give off a specific color when exposed to a specific wavelength of light.\u00a0 With the GFP-labeled cells, Dr. Wei and her team can visualize cell-cell and cell-scaffold interactions and identify the origin of the cells, whether they are from the original bone or from donor cells, how each of those sources of cells contributes to bone repair and how those cells interact over time.\u00a0 This information can provide important insights into the analysis and development of new and existing bone repair procedures.<\/p>\n In addition to these grants, Dr. Wei has also recently received funding to organize a symposium at the Materials Research Society fall meeting, entitled \u201cBiomaterials for Tissue Regeneration.\u201d\u00a0 This symposium will bring together 12 distinguished members of the field to present their research and facilitate the development of new, important research in the field of tissue regeneration.<\/p>\n","protected":false},"excerpt":{"rendered":" Dr. Mei Wei, a faculty member in the department of Chemical, Materials & Biomolecular Engineering and the Institute of Materials Science, has recently received two large grants from the National Institutes of Health (NIH) and the National Science Foundation (NSF) in collaboration with David Rowe, M.D., Director of the Center for Regenerative Medicine & Skeletal Biology and a professor of Reconstructive Sciences in the School of Dental Medicine at the UCHC. This funding will allow her to expand upon her ongoing work in tissue regeneration and engineering.<\/p>\n","protected":false},"author":122,"featured_media":211891,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_crdt_document":"","wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[1866],"tags":[],"magazine-issues":[],"coauthors":[2110],"class_list":["post-203547","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-engr"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-23 03:31:15","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/203547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=203547"}],"version-history":[{"count":1,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/203547\/revisions"}],"predecessor-version":[{"id":224952,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/203547\/revisions\/224952"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/211891"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=203547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=203547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=203547"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=203547"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=203547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/d45h139.public.uconn.edu\/sites\/news\/wp-content\/uploads\/2011\/12\/wei2b.jpg\" "\\"wei2b\\"")
<\/a>at can mimic human tissue and encourage cartilage regeneration around joints.\u00a0 A project like this has important implications for joint disorders, especially osteoarthritis, a painful and debilitating disease.\u00a0 The NIH-funded project involves the exploration of new bone imaging techniques that will offer researchers insight into the interaction of scaffolds and cells at different stages of bone repair.<\/p>\n![\"\"](\"http:\/\/d45h139.public.uconn.edu\/sites\/news\/wp-content\/uploads\/2011\/12\/wei2a.jpg\" "\\"wei2a\\"")
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