{"id":203918,"date":"2019-07-29T14:06:52","date_gmt":"2019-07-29T14:06:52","guid":{"rendered":"http:\/\/d45h139.public.uconn.edu\/sites\/news\/?p=29263"},"modified":"2019-07-29T14:06:52","modified_gmt":"2019-07-29T14:06:52","slug":"common-steroid-could-soften-up-tumors-for-chemo","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2019\/07\/common-steroid-could-soften-up-tumors-for-chemo\/","title":{"rendered":"Common Steroid Could Soften Up Tumors for Chemo"},"content":{"rendered":"<figure id=\"attachment_29264\" aria-describedby=\"caption-attachment-29264\" style=\"width: 768px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-29264 img-responsive lazyload\" data-src=\"http:\/\/d45h139.public.uconn.edu\/sites\/news\/wp-content\/uploads\/StuberACSNano2019-768x512.jpg\" alt=\"\" width=\"768\" height=\"512\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 768px; --smush-placeholder-aspect-ratio: 768\/512;\" \/><figcaption id=\"caption-attachment-29264\" class=\"wp-caption-text\">(Image Courtesy of John Martin, University of Tokyo, and Matthew Stuber, UConn)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><strong>By: Kim Krieger, UConn Communications<\/strong><\/p>\n<p>A common drug used to alleviate side effects of cancer treatment may also make the treatment more successful if given beforehand, report a consortium of research institutions including the University of Connecticut.<\/p>\n<p>Dexamethasone, a steroid often given to decrease swelling and nausea, and relieve side effects of chemotherapy treatments for cancer, may also enhance the effectiveness of the chemotherapy itself, the researchers r<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.8b07865\">eported in <em>ACS Nano<\/em><\/a>.<\/p>\n<p>Cancerous tumors tend to grow abnormal blood vessels. Squished, twisted, and compressed, these blood vessels inside tumors also tend to be leaky.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>\u201cThis creates low pressure in the blood vessel, while the tumor tissue has high pressure. And you can\u2019t flow from low to high pressure,\u201d says Matthew Stuber, UConn assistant professor of chemical and biological engineering, and study author. <span class=\"Apple-converted-space\">The low pressure in the blood vessels makes it hard for the chemotherapy drugs to penetrate the interior of the tumor.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/today.uconn.edu\/2019\/07\/common-steroid-soften-tumors-chemo\/\">Click here to read more on UConn Today\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A common drug used to alleviate side effects of cancer treatment may also make the treatment more successful if given beforehand, report a consortium of research institutions including the University of Connecticut.<\/p>\n","protected":false},"author":122,"featured_media":29265,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_crdt_document":"","wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[1866],"tags":[],"magazine-issues":[],"coauthors":[],"class_list":["post-203918","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-engr"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-20 05:51:53","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/203918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/122"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=203918"}],"version-history":[{"count":0,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/203918\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/29265"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=203918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=203918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=203918"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=203918"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=203918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}