{"id":204981,"date":"2023-09-22T09:17:39","date_gmt":"2023-09-22T13:17:39","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=204981"},"modified":"2023-11-06T15:36:50","modified_gmt":"2023-11-06T20:36:50","slug":"student-led-research-explores-breakthrough-treatment-of-systemic-diseases","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2023\/09\/student-led-research-explores-breakthrough-treatment-of-systemic-diseases\/","title":{"rendered":"Student Led Research Explores Breakthrough Treatment of Systemic Diseases"},"content":{"rendered":"

Pharmacology and Toxicology professors Xiaobo Zhong, Jos\u00e9 Manautou, Theodore Rasmussen, and Raman Bahal and their research students have spent the last year working collaboratively to investigate new and more effective treatment options of antisense oligonucleotide (ASO) and small interfering RNA (siRNA) drugs for systemic diseases of liver origin in a review article published in Pharmacological Reviews.\u00a0 Their work was inspired by recent graduate May Zhang\u2019s thesis: The Growth of siRNA-based Therapeutics: Updated Clinical Studies<\/em> (Zhang et al., 2021, PMID:33513339).\u00a0 Her work inspired Zhong and other SoP faculty to task their current students to explore the effects of nucleic acid therapeutics on the liver, which is often where many diseases begin to form.<\/p>\n

The students, made up of School of Pharmacy pre-professional, professional, Ph.D., and CLAS students, worked within the larger group, in subgroups, and independently.\u00a0 In the larger group the students drafted an introduction and conclusion, were taught an overview of the topic, and exchanged feedback. The groups were divided up into subgroups to tackle two main topics: systemic diseases of liver origin and the corresponding treatments of nucleic acid therapeutics.\u00a0 Independently, the students focused on writing about one specific disease and associated nucleic acid drugs as their contribution to the paper, covering eight rare and common diseases and 15 drugs.\u00a0 Once the paper was completed the students revered their experience, saying it was an exceptional exercise in applying what they learned in the classroom to a real-world situation.<\/p>\n

\u201cI have been part of Dr. Zhong’s lab for a year now and being in this Lab helped me connect what I learned in class to the real world of pharmacy,\u201d says Pharm.D. student, Alicia Zongxun Wang. \u201cI learned not only about siRNA drugs from writing this paper, but I also learned how to produce a scholarly article and analyze drug trial data, which bridged my learning from various classes in school to the clinical world.\u201d<\/p>\n

Many students felt the experience not only made them better writers but improved their experience working in groups and as well as independently.\u00a0 \u201cWorking on this project with Dr. Zhong and the other faculty was my first research experience, and it was so valuable,\u201d says Pharm.D. student, Jordyn Belcourt. \u201cMost people think of research as doing experiments in a lab, but that\u2019s not the only way. In this project, we gathered existing information and came to new conclusions using clinical trial data. It was a new skill I had to learn. I was appreciative that I got to start working with a small team and then moved onto an independent section. It allowed me to gain confidence over time. This was a huge collaborative effort that wouldn\u2019t have been possible without every member of the team putting in their best effort.\u201d<\/p>\n

Zhong expressed pride in his students and gratitude for all their hard work this past year.\u00a0 This article cited an almost unheard of 300 sources and has laid the foundation for his lab to investigate the possible usage of RNA-based therapies as treatment for rare and common diseases.<\/p>\n

\u201cThis comprehensive review explores groundbreaking approaches to treat systemic diseases of liver origin through nucleic acid therapeutics,\u201d says Zhong. \u201cWe have delved deep into the potential of these innovative therapeutics and their impact on liver-originated diseases. Whether you are a researcher, clinician, or simply interested in the future of liver disease treatment, this paper is a valuable resource. I encourage people to check out the paper and share it with colleagues and throughout their network. This kind of support can help spread awareness and drive further research in this crucial area.”<\/p>\n

Student Authors: Aarush Kolli (Pre-Pharmacy), Anagha Gogate (P2), Jordyn Belcourt (P1), Milan Shah (P3), Alicia Zongxun Wang (P1), Alexis Frankel (P1), Sherouk Tawfik (PHARM Ph.D. candidate), and Jing Jin (PHARM Ph.D. candidate), Holly Kolmel, (CLAS Pre-Med), Matthew Chalon (CLAS Biomedical Sciences), and Prajith Stephen (CLAS PNB)<\/p>\n

Read the journal article here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Students from the School of Pharmacy (PHARM) and the College of Liberal Arts and Sciences (CLAS) came together to research, write, and publish their research on breakthrough nucleic acid therapeutics treatments. <\/p>\n","protected":false},"author":187,"featured_media":205156,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_crdt_document":"","wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[2226,1864],"tags":[],"magazine-issues":[],"coauthors":[2449],"class_list":["post-204981","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clas","category-pharm"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-01 05:34:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/204981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/187"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=204981"}],"version-history":[{"count":8,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/204981\/revisions"}],"predecessor-version":[{"id":206685,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/204981\/revisions\/206685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/205156"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=204981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=204981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=204981"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=204981"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=204981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}