{"id":235759,"date":"2025-09-24T13:05:18","date_gmt":"2025-09-24T17:05:18","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=235759"},"modified":"2025-09-24T13:05:18","modified_gmt":"2025-09-24T17:05:18","slug":"most-outstanding-abstract-honors-for-dr-ernesto-canalis-of-uconn","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2025\/09\/most-outstanding-abstract-honors-for-dr-ernesto-canalis-of-uconn\/","title":{"rendered":"Most Outstanding Abstract Honors for Dr. Ernesto Canalis of UConn"},"content":{"rendered":"

The research of Dr. Ernesto Canalis<\/a> of UConn School of Medicine was highly honored at the annual meeting of the American Society of Bone and Mineral Research (ASBMR) this September.<\/p>\n

Canalis\u2019 presented basic science abstract, \u201cActivation of NOTCH3 Precludes Corticalization and Skeletal Integrity,\u201d<\/a> received the 2025 ASBMR Most Outstanding Basic Abstract Award.<\/p>\n

The award was bestowed upon Canalis as the lead investigator of the highest-ranking abstract submitted for presentation at the ASBMR\u2019s Annual Meeting in the basic science category.<\/p>\n

\u201cBeing selected is an honor and highlights the importance of our work,\u201d shared Canalis. His best abstract honor was announced during the annual meeting\u2019s highlights and awards ceremony.<\/p>\n

The award honors the Canalis lab\u2019s work in a very prominent way. In fact, it was selected from over 1,000 submitted abstracts.<\/p>\n

\"2025
2025 ASBMR Most Outstanding Basic Abstract Award winner Dr. Ernesto Canalis of UConn School of Medicine with Jennifer Westendorf, Ph.D., president of ASBMR. (Photo courtesy of ASBMR)<\/figcaption><\/figure>\n

Canalis serves as professor of orthopaedic surgery and medicine at UConn School of Medicine and director of the Center for Skeletal Research. He is also co-director of the UConn Musculoskeletal Institute of the Department of Orthopaedic Surgery\u00a0at UConn Health.<\/p>\n

Canalis is an internationally renowned physician-scientist in bone metabolism. His laboratory is known for the discovery of skeletal growth factors and has pursued important investigations on the role of growth factors and their antagonists in skeletal function.\u00a0 His lab has made seminal contributions to our understanding of the mechanisms of glucocorticoid action in bone in an effort to explain the pathogenesis of glucocorticoid induced osteoporosis and correct the disease.\u00a0 The laboratory\u2019s recent work has centered on factors determining osteoblast and osteoclast cell fate and function.<\/p>\n

These investigations include studies on the role of Notch signaling in osteoblast and osteoclast cell differentiation.\u00a0 Cellular and genetically engineered mouse models are used for the research conducted by the group.\u00a0 The laboratory is particularly interested in translational research and has created genetically engineered mouse models of Hajdu Cheney Syndrome and Lateral Meningocele Syndrome, devastating diseases characterized by bone loss and fractures.\u00a0 The studies have allowed the team to determine mechanisms of the bone loss and are exploring ways to prevent the skeletal disease. Recently, a mouse model of non-classical osteogenesis imperfecta was created. These mouse lines have allowed the study of mechanisms relevant to disease pathogenesis and the development of novel therapeutic avenues, including the use of antisense oligonucleotides.<\/p>\n

As part of Canalis\u2019 recent work, the laboratory investigated the mechanisms that lead to the formation of cortical bone during early life, but with an impact on skeletal health throughout the life of the individual. Impaired formation of cortical bone could lead to bone fragility and fractures later in life. The findings of this work formed the basis of the abstract presented at the 2025 annual meeting of the ASBMR.<\/p>\n

The Canalis laboratory has been continuously funded by the National Institutes of Health (NIH) since 1981. In 1990 it received a MERIT Award from the National Institute of Musculoskeletal and Skin Disorders (NIAMS).\u00a0 Currently, the laboratory is funded by NIAMS.<\/p>\n