{"id":27732,"date":"2011-01-07T08:19:08","date_gmt":"2011-01-07T13:19:08","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=27732"},"modified":"2011-08-05T10:01:07","modified_gmt":"2011-08-05T14:01:07","slug":"uconn-cardiologists-uncover-new-heart-attack-warning-sign","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2011\/01\/uconn-cardiologists-uncover-new-heart-attack-warning-sign\/","title":{"rendered":"UConn Cardiologists Uncover New Heart Attack Warning Sign"},"content":{"rendered":"<figure id=\"attachment_27725\" aria-describedby=\"caption-attachment-27725\" style=\"width: 291px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/today.uconn.edu\/wp-content\/uploads\/2011\/01\/LIANG98_lg.jpg\"><img decoding=\"async\" class=\"size-full wp-image-27725  img-responsive lazyload\" data-src=\"https:\/\/today.uconn.edu\/wp-content\/uploads\/2011\/01\/LIANG98_lg.jpg\" alt=\"&lt;p&gt;Bruce Liang, M.D., director of the Pat and Jim Calhoun Cardiology Center and chief of cardiology. Photo by Peter Morenus&lt;\/p&gt;\" width=\"291\" height=\"192\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 291px; --smush-placeholder-aspect-ratio: 291\/192;\" \/><\/a><figcaption id=\"caption-attachment-27725\" class=\"wp-caption-text\">Dr. Bruce Liang, director of the Pat and Jim Calhoun Cardiology Center and chief of cardiology at the UConn Health Center. Photo by Peter Morenus<\/figcaption><\/figure>\n<p>Health Center cardiologists have identified a protein fragment that when detected in the blood can be a predictor of heart attack.<\/p>\n<p>Their research, led by <a href=\"http:\/\/heart.uchc.edu\/physicians\/bios\/liang.html\" target=\"_blank\">Dr. Bruce Liang<\/a>, director of the Pat and Jim Calhoun Cardiology Center, is published in the Jan. 11 issue of the <a href=\"http:\/\/content.onlinejacc.org\/\" target=\"_blank\"><em>Journal of the American College of Cardiology<\/em><\/a>. The <a href=\"http:\/\/content.onlinejacc.org\/cgi\/reprint\/57\/2\/220.pdf\" target=\"_blank\">study<\/a> found that heart attack patients had elevated levels of the protein fragment known as Caspase-3 p17 in their blood.<\/p>\n<p>&#8220;We\u2019ve discovered a new biomarker for heart attack, and showed that apoptosis, or a particular kind of cell death, is a cause of heart muscle damage,&#8221; Liang says. &#8220;The ability to see a heart attack coming with a simple blood test and to develop new therapies to block apoptosis would enable us to get a head start on treatment and preserve crucial heart muscle and cardiac function.&#8221;<\/p>\n<p>&#8220;This test can work in patients but has not met regulatory requirements for clinical application in patients suspected of having a heart attack,&#8221; Liang says. &#8220;If it is successfully applied one day, it would mean another way to diagnose heart attack, and the possible development of new treatments.&#8221;<\/p>\n<p>Co-investigators include Drs. Mariela Agosto, <a href=\"http:\/\/heart.uchc.edu\/physicians\/bios\/azrin.html\" target=\"_blank\">Michael Azrin<\/a>, and <a href=\"http:\/\/heart.uchc.edu\/physicians\/bios\/singh.html\" target=\"_blank\">Kanwar Singh<\/a> from the UConn Health Center, and Dr. Allan Jaffe from the Mayo Clinic and Mayo Medical School, Rochester, Minn.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Bruce Liang led research on a protein fragment that is a likely biomarker for heart attack.<\/p>\n","protected":false},"author":111,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[1],"tags":[],"magazine-issues":[],"coauthors":[57,2010],"class_list":["post-27732","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-22 06:48:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/27732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/111"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=27732"}],"version-history":[{"count":5,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/27732\/revisions"}],"predecessor-version":[{"id":43271,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/27732\/revisions\/43271"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=27732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=27732"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=27732"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=27732"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=27732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}