{"id":68785,"date":"2012-11-30T08:16:35","date_gmt":"2012-11-30T13:16:35","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=68785"},"modified":"2012-12-10T10:24:42","modified_gmt":"2012-12-10T15:24:42","slug":"uconn-researcher-dopamine-not-about-pleasure-anymore","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2012\/11\/uconn-researcher-dopamine-not-about-pleasure-anymore\/","title":{"rendered":"UConn Researcher: Dopamine Not About Pleasure (Anymore)"},"content":{"rendered":"
\"John<\/a>
John Salamone, professor of psychology, at his office. (Peter Morenus\/UConn Photo)<\/figcaption><\/figure>\n

To John Salamone, professor of psychology and longtime researcher of the brain chemical dopamine, scientific research can be very slow-moving.<\/p>\n

\u201cIt takes a long time for things to change in science,\u201d he says. \u201cIt\u2019s like pulling on the steering wheel of an ocean liner, then waiting for the huge ship to slowly turn.\u201d<\/p>\n

Salamone, a UConn Board of Trustees Distinguished Professor, has spent most of his career battling a particular long-held scientific idea: the popular notion that high levels of brain dopamine are related to experiences of pleasure. As increasing numbers of studies show, he says, the famous neurotransmitter is not responsible for pleasure, but has to do with motivation.<\/p>\n

He summarizes and comments on the evidence for this shift in thinking in a Nov. 8 review in the Cell Press journal Neuron<\/em><\/a>.<\/p>\n

In the early 1980\u2019s, explains Salamone, the National Institute on Drug Abuse put out a call for research on the neurological basis for drug abuse and addiction.<\/p>\n

The research that ensued built support for the idea that when the brain produced elevated amounts of dopamine, it was accompanied by perceptions of pleasure. The chemical quickly became known for this relationship, which was thought to be important for responding to drugs and other motivational substances, such as food.<\/p>\n

The chemical, which was formerly only thought to play a small role in movement, became over the subsequent decades among the most well-known and important in the brain. It turned out to be so important that it found its way into popular culture, with dozens of self-help books and websites explaining its relationship to feelings of happiness and reward.<\/p>\n

But over time, Salamone\u2019s studies and those of others started revealing problems. In animals, dopamine levels can spike after stress, such as losing a fight with another animal. Soldiers dealing with post-traumatic stress disorder also show activity in dopamine-rich parts of the brain when hearing recorded gunshots and other combat sounds.<\/p>\n

Low levels of dopamine make people and other animals less likely to work for things, so it has more to do with motivation and cost\/benefit analyses than pleasure itself.<\/p><\/blockquote>\n

So if dopamine was really the pleasure element, then why all this association with negative experiences?<\/p>\n

Salamone\u2019s research over the past 15 years has attempted to find an answer to that question. His work involves artificially raising or lowering dopamine levels in animals, then giving them a choice between two rewards with different value, which can be obtained through different amounts of work.<\/p>\n

For example, what will a rat do when on one end of a corridor there\u2019s a pile of food, but on the other end there\u2019s a pile of food twice as big with a small fence to jump over on the way?<\/p>\n

As Salamone\u2019s studies have showed, animals with lowered levels of dopamine almost always choose the easy, low-value reward, while animals with normal levels don\u2019t mind exerting the effort to jump the fence for the high-value reward.<\/p>\n

Other studies in humans have corroborated these results, such as research with depressed patients.<\/p>\n

\u201cOften, depressed people say they don\u2019t want to go out with their friends,\u201d says Salamone. But it\u2019s not that they don\u2019t experience pleasure, he says \u2013 if their friends were around, many depressed people could have fun.<\/p>\n

\u201cLow levels of dopamine make people and other animals less likely to work for things, so it has more to do with motivation and cost\/benefit analyses than pleasure itself,\u201d he explains.<\/p>\n

In essence, says Salamone, this is how amphetamines work, which increase dopamine levels and help people motivate to focus on tasks at hand.<\/p>\n

\u201cWhen you give people amphetamines, you see them putting more effort into things,\u201d he says.<\/p>\n

The big implications of this change in understanding come at the level of overlapping motivational symptoms of depression with those seen in other disorders such as schizophrenia, multiple sclerosis, and Parkinson\u2019s disease. Symptoms of fatigue may be related to low levels of dopamine or changes in other parts of the same brain circuitry.<\/p>\n

On the one hand, this lack of perceived energy is maladaptive, because it reduces the tendency to interact with the environment. But, Salamone says, it could also reflect the body\u2019s attempt to save energy in a crisis.<\/p>\n

He points out that new ideas in science are traditionally met with criticism. But after all the mounting evidence, he says he\u2019s no longer regarded as \u201ca crazy rebel,\u201d but simply someone who thought differently.<\/p>\n

\u201cScience is not a collection of facts. It\u2019s a process,\u201d he says. \u201cFirst we thought dopamine was involved only in movement. Then that faded and we thought it was pleasure. Now we\u2019ve gone beyond that data on pleasure.\u201d<\/p>\n

Although he has thought about writing a popular-press book, he\u2019s not sure he really wants to go to the public and \u201cdebunk\u201d the dopamine hypothesis of pleasure and reward. But if he ever does, one thing is for sure.<\/p>\n

\u201cI can sum up all this work with one phrase, which would make a great book title,\u201d he says. \u201cDopamine: it\u2019s not about pleasure anymore.\u201d<\/p>\n

Salamone\u2019s work has been funded by the National Institute of Mental Health, a division of the National Institutes of Health, and by the National Institute on Drug Abuse. His co-author is Merc\u00e8 Correa of the Universitat Jaume I in Spain.<\/p>\n","protected":false},"excerpt":{"rendered":"

Contrary to a long-held scientific idea, psychologist John Salamone says an increasing number of studies show that the neurotransmitter has to do not with pleasure but with motivation. <\/p>\n","protected":false},"author":37,"featured_media":68784,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[2076,1],"tags":[],"magazine-issues":[],"coauthors":[63],"class_list":["post-68785","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-uncategorized"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-17 01:55:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/68785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=68785"}],"version-history":[{"count":5,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/68785\/revisions"}],"predecessor-version":[{"id":69903,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/68785\/revisions\/69903"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/68784"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=68785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=68785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=68785"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=68785"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=68785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}