{"id":91135,"date":"2014-04-02T12:10:12","date_gmt":"2014-04-02T16:10:12","guid":{"rendered":"https:\/\/today.uconn.edu\/?p=91135"},"modified":"2014-04-23T09:27:52","modified_gmt":"2014-04-23T13:27:52","slug":"finding-genetic-links-to-personal-health-and-fitness","status":"publish","type":"post","link":"https:\/\/today.uconn.edu\/2014\/04\/finding-genetic-links-to-personal-health-and-fitness\/","title":{"rendered":"Finding Genetic Links to Personal Health and Fitness"},"content":{"rendered":"
\"Students<\/a><\/div>\n

With obesity now a national epidemic, doctors, nutritionists, and exercise professionals are doing everything they can to encourage people to lead healthier lives, and that includes participating in regular, sustained weekly exercise.<\/p>\n

But not everyone is cut out for running three miles a day or lifting weights at the gym four times a week. So what do you do? Exercise and fitness expert Linda Pescatello, Board of Trustees Distinguished Professor of Kinesiology, is part of a group of scientists exploring our genes to find ways to match the right forms of exercise to our body\u2019s genetic makeup in order to achieve the maximum health benefits.<\/p>\n

\"Linda<\/a>
Linda Pescatello, Board of Trustees Distinguished Professor of Kinesiology, with a test subject and spotter demonstrating a weight training exercise. (File photo)<\/figcaption><\/figure>\n

Pescatello recently participated in one of the largest genetics-based exercise studies ever undertaken. She will provide an overview of her findings<\/a> in a lecture titled \u201cWhy Don\u2019t My Designer Jeans Fit? It\u2019s Because of My Genes!\u201d on May 1 as part of the UConn Center for Health Intervention and Prevention\u2019s (CHIP) spring lecture series on Genomics and Health Behavior. The lecture is free and open to the public.<\/p>\n

Through the group\u2019s research, Pescatello has found that an individual\u2019s genetic makeup can lead them to prefer certain intensities of exercise, and therefore, genetic predisposition can impact a person\u2019s ability to lose weight or increase their fitness.<\/p>\n

But that doesn\u2019t mean individuals whose genetic makeup is predisposed to be less impacted by vigorous exercise should just give up and embrace a couch potato lifestyle, says Pescatello. Just the opposite is true.<\/p>\n

\u201cPeople shouldn\u2019t feel a sense of fatalism that no matter what they do, because of their genes that is what they are going to become,\u201d says Pescatello. \u201cGenes do lead to certain predispositions for different traits. However, those genetic tendencies can be modified. We call that effect mediation,<\/i> and one of the best effect mediators when it comes to being overweight is physical activity. You might not lose as much weight as another person who is more genetically inclined to benefit from rigorous exercise, but if you weren\u2019t exercising at all, you could still be 20 pounds heavier.\u201d<\/p>\n

Pescatello\u2019s research group embarked on the exercise study in 2001 hoping to identify key genes that were directly associated with exercise and fitness. What they found, however, was that the influence of specific genes is extremely complex, and variables such as a person\u2019s clinical characteristics (their body\u2019s conditioning level, their gender, or body type) and personal behavior (diet, sleep habits, exercise preferences) can have a significant impact on their health outcomes.<\/p>\n

Ultimately, the team, along with other researchers, hopes to map key genes and regulatory factors that predict the way a person will respond to exercise. Pescatello says this could someday allow physicians to prescribe tailored exercise regimens that match the right person with the right exercise prescription, in order to provide the maximum health benefits for a targeted health outcome, such as weight loss or disease mitigation.<\/p>\n

\u201cThe current prescription for weight loss or successful weight loss maintenance is large amounts of moderate-intensity exercise upwards of five hours a week,\u201d says Pescatello. \u201cBut if the person you\u2019re prescribing to isn\u2019t predisposed to respond to it, you are probably better off writing an exercise prescription that the individual is more likely to adhere to over the long haul. That kind of regimen would have a greater influence on weight gain or successful weight loss maintenance.\u201d<\/p>\n

In other words, she says, if a person is genetically predisposed to not gain significant health benefits from running long distances and is likely not to adhere to an exercise regimen requiring running a certain distance daily, than it would be better for a health care or exercise professional to prescribe another aerobic activity. Walking or Zumba, or perhaps resistance training like weight lifting, may be something the patient is more genetically inclined to benefit from.<\/p>\n

Even though the benefit of regular exercise is clearly proven, only about a third of physicians today prescribe exercise for their patients, Pescatello says. Some patients may be reluctant to exercise because they feel what is required is too difficult, or they may not feel it will help their condition in the long run. If health care and exercise professionals know a patient\u2019s genetic predispositions and then tailor an exercise regimen that would maximize results relative to effort, the patient may be more inclined to participate.<\/p>\n

\u201cIf we could truly develop the right exercise prescriptions for the right people, obviously the effectiveness of exercise would be improved,\u201d she says.<\/p>\n

Pescatello\u2019s presentation on May 1 is from 12:30 to 1:30 p.m. in Room 204 of the J. Ray Ryan Building in Storrs, and will be followed by a brainstorming workshop from 2 to 3:30 p.m. The workshop, \u201cOvercoming the Hurdles to Designing Personalized Approaches to Lifestyle Risk Reduction Strategies,\u201d features panelists Marc Lalande (UConn Institute for Systems Genomics), George Weinstock (JAX Genomic Medicine), Brenton Graveley, (professor of genetics and developmental biology, UConn Health), and Deborah Fein (UConn Distinguished Professor of Psychology). The panel will be moderated by Pescatello.<\/p>\n

The CHIP lecture series is designed to provide a forum for CHIP investigators, affiliates, and research staff to hear presentations and new work in development by leading national figures in health behavior intervention and prevention. A complete schedule for the Spring 2014 Lecture Series can be found here<\/a>. The next lecture, on April 3, will feature Lisa Aspinwall from the University of Utah. Aspinwall will discuss genetic testing and the proactive management of familial melanoma risk.<\/p>\n","protected":false},"excerpt":{"rendered":"

Kinesiologist Linda Pescatello is exploring ways to match the right forms of exercise to the body\u2019s genetic makeup to achieve maximum health benefits.<\/p>\n","protected":false},"author":12,"featured_media":81690,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"wds_primary_series":0,"wds_primary_attribution":0,"footnotes":""},"categories":[2076,179,1],"tags":[],"magazine-issues":[],"coauthors":[44],"class_list":["post-91135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-uconn-health","category-uncategorized"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-07-20 07:43:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/91135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/comments?post=91135"}],"version-history":[{"count":5,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/91135\/revisions"}],"predecessor-version":[{"id":92256,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/posts\/91135\/revisions\/92256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media\/81690"}],"wp:attachment":[{"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/media?parent=91135"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/categories?post=91135"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/tags?post=91135"},{"taxonomy":"magazine-issue","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/magazine-issues?post=91135"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/today.uconn.edu\/wp-rest\/wp\/v2\/coauthors?post=91135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}