Daniel Bolnick is interested in how evolution maintains genetic variation within species. Natural selection is usually thought of as a filtering process that removes all but the most-fit variants within a population, thus reducing variation. Yet, most natural populations of organisms harbor substantial genetic diversity. Bolnick’s research explores several possible solutions to this paradox. For instance, he has shown that when animals compete strongly for a variety of food sources, individuals who use atypical foods tend to escape the ill effects of competition, thereby favoring dietary diversity and any genetic traits that create this diversity.
Recently, his work has focused on how parasites and their hosts co-evolve, and how their antagonism shapes variation in host immunity. As with competition, rare types can gain an advantage, for instance when hosts fail to recognize parasites with rare molecular fingerprints, those atypical parasites are maintained in their population. This curiosity-driven work on the evolutionary ‘arms race’ between hosts and parasites has led his lab into studying how vertebrates’ immune response can inflict self-damage, such as severe fibrosis. This scar tissue formation is the basis of several severe human diseases, but in the fish this fibrosis is an adaptive defense against parasites.
Areas of Expertise
University of California - Davis
The David Star Jordan Prize
2015 The prize is international in scope and presented approximately every three years to a young scientist (40 years of age or less) who is making novel innovative contributions in one or more areas of Jordan’s interest: evolution, ecology, population and organismal biology.
George Mercer Award
2005 Awarded by the Ecological Society of America for an outstanding ecological research paper published within the past two years by a younger researcher (less than 40 years old).
Daniel Bolnick, Editor in Chief of "The American Naturalist"
New Books Network online
Listen to this interview of Daniel Bolnick, Editor in Chief of The American Naturalist and Professor of evolution and ecology at the University of Connecticut. We talk about the role of research journals today and we talk about the location of research journals in the big endeavor that is called science.
In the Era of COVID-19, Fieldwork Is Scrappy and Socially Distant
Atlas Obscura online
If May 2020 was like any other spring, Daniel Bolnick, an ecologist at the University of Connecticut, would be wrapping up a semester of teaching and preparing to head into the field. He and as many as two-dozen collaborators would be fanning out to sites in Alaska and Canada’s Vancouver Island, where they would traverse lush forests with snow-capped mountains in the distance, and splosh into lakes and streams.
How species improve their success
Phys Org online
Researchers Pim Edelaar at Pablo de Olavide University (Seville, Spain) and Daniel Bolnick at the University of Connecticut (U.S.) have developed a classification of the ways that species can improve their success in relation to their environment. This theoretical framework is a conceptual tool that helps to understand and contemplate the total range of options that an organism has to relate to its environment, recognizing all the processes that may be relevant in the real world (such as in biology, medicine, sociology and economics)...
REAL HEROES HAVE THE GUTS TO ADMIT THEY'RE WRONG
WHAT DO YOU do when you discover you’re wrong? That’s a conundrum Daniel Bolnick recently faced. He’s an evolutionary biologist, and in 2009 he published a paper with a cool finding: Fish with different diets have quite different body types. Biologists had suspected this for years, but Bolnick offered strong confirmation by collecting tons of data and plotting it on a chart for all to see. Science for the win!
Outnumbered and on others' turf, misfits sometimes thrive
Phys Org online
"One hundred years of evolutionary theory is built around the idea that immigrants from one population dropped into another population of the same species don't do well," says Daniel Bolnick, a professor of integrative biology and the primary investigator on the study published today in the journal Nature. "Such immigrants are usually rare, and we have found that sometimes their rarity provides a competitive edge..."
Diet Affects Men’s and Women’s Gut Microbes Differently
“Our study asks not just how diet influences the microbiome, but it splits the hosts into males and females and asks, do males show the same diet effects as females?” said Daniel Bolnick, professor in The University of Texas at Austin’s College of Natural Sciences and lead author of the study...
Evolutionary gain and loss of a pathological immune response to parasitismScience
Three-spined sticklebacks are nominally marine species, but after the Pleistocene glacial retreat, they colonized freshwater lakes widely. Weber et al. have capitalized on the divergent populations that arose to test ideas about the costs of immune responses in animals. Using a combination of wild and laboratory-created hybrids, the authors found that lakes contained fish with differences in immune responsiveness and different susceptibilities to a tapeworm parasite. Fish that mounted an extreme immune response, as measured by fibrosis, showed a marked reduction in fecundity. Immune response–related loci show evidence of opposing selection among resistant and susceptible populations. The ecological conditions that have caused these divergences remain unidentified, but knowledge of the genes involved does indicate a way to investigate immune costs in other species.
(Non)Parallel EvolutionAnnual Review of Ecology, Evolution and Systematics
2018 Parallel evolution across replicate populations has provided evolutionary biologists with iconic examples of adaptation. When multiple populations colonize seemingly similar habitats, they may evolve similar genes, traits, or functions. Yet, replicated evolution in nature or in the laboratory often yields inconsistent outcomes: Some replicate populations evolve along highly similar trajectories, whereas other replicate populations evolve to different extents or in distinct directions. To understand these heterogeneous outcomes, biologists are increasingly treating parallel evolution not as a binary phenomenon but rather as a quantitative continuum ranging from parallel to nonparallel. By measuring replicate populations’ positions along this (non)parallel continuum, we can test hypotheses about evolutionary and ecological factors that influence the extent of repeatable evolution. We review evidence regarding the manifestation of (non)parallel evolution in the laboratory, in natural populations, and in applied contexts such as cancer. We enumerate the many genetic, ecological, and evolutionary processes that contribute to variation in the extent of parallel evolution.
Systematic analysis of complex genetic interactionsAmerican Association for the Advancement of Science
2018 Genetic interactions occur when mutations in different genes combine to result in a phenotype that is different from expectation based on those of the individual mutations. Negative genetic interactions occur when a combination of mutations leads to a fitness defect that is more exacerbated than expected. For example, synthetic lethality occurs when two mutations, neither of which is lethal on its own, generate an inviable double mutant.
Many‐to‐one form‐to‐function mapping weakens parallel morphological evolutionEvolution
2017 Evolutionary ecologists aim to explain and predict evolutionary change under different selective regimes. Theory suggests that such evolutionary prediction should be more difficult for biomechanical systems in which different trait combinations generate the same functional output: “many‐to‐one mapping.” Many‐to‐one mapping of phenotype to function enables multiple morphological solutions to meet the same adaptive challenges.
Gene Expression Contributes to the Recent Evolution of Host Resistance in a Model Host Parasite SystemFrontiers in Immunology
2017 Heritable population differences in immune gene expression following infection can reveal mechanisms of host immune evolution. We compared gene expression in infected and uninfected threespine stickleback (Gasterosteus aculeatus) from two natural populations that differ in resistance to a native cestode parasite, Schistocephalus solidus. Genes in both the innate and adaptive immune system were differentially expressed as a function of host population, infection status, and their interaction.
Gene expression stasis and plasticity following migration into a foreign environmentMolecular Ecology
2017 Selection against migrants is key to maintaining genetic differences between populations linked by dispersal. However, migrants may mitigate fitness costs by proactively choosing among available habitats, or by phenotypic plasticity. We previously reported that a reciprocal transplant of lake and stream stickleback (Gasterosteus aculeatus) found little support for divergent selection.