The popularity -- and price -- of brand-name injectable drugs like Ozempic, Wegovy, Mounjaro, and Zepbound has skyrocketed. But the soaring demand for these drugs -- used for weight loss as well as to control blood sugar levels and reduce the risk of heart disease -- and the limited supply as well as lack of generic options has also led to a flood of non-brand alternatives in the market. In a recent article for The Conversation, UConn expert C. Michael White, Distinguished Professor of Pharmacy Practice, issued a warning to consumers about the potential undisclosed risks of these off-brand products: High demand is driving GLP-1 wannabes The dietary supplement market has sought to cash in on the GLP-1 demand with pills, teas, extracts and all manner of other products that claim to produce similar effects as the brand names at a much lower price. Products containing the herb berberine offer only a few pounds of weight loss, while many dietary supplement weight loss products contain stimulants such as sibutramine and laxatives such as phenolphthalein, which increase the risk of heart attacks, strokes and cancer. The role of compounding pharmacies Unlike the dietary supplements that are masquerading as GLP-1 weight loss products, compounding pharmacies can create custom versions of products that contain the same active ingredients as the real thing for patients who cannot use either brand or generic products for some reason. These pharmacies can also produce alternative versions of brand-name drugs when official drug shortages exist. Since the demand for GLP-1 medications has far outpaced the supply, compounding pharmacies are legally producing a variety of different semaglutide and tirzepatide products. These products may come in versions that differ from the brand-name companies, such as vials of powder that must be dissolved in liquid, or as tablets or nasal sprays. Just like the brand-name drugs, you must have a valid prescription to receive them. The prices range from $250-$400 a month – still a steep price for many consumers. Compounding pharmacies must adhere to the FDA’s sterility and quality production methods, but these rules are not as rigorous for compounding pharmacies as those for commercial manufacturers of generic drugs. In addition, the products compounding pharmacies create do not have to be tested in humans for safety or effectiveness like brand-name products do. Proper dosing can also be challenging with compounded forms of the drugs. Companies that work the system For people who cannot afford a compounding pharmacy product, or cannot get a valid prescription for semaglutide or tirzepatide, opportunistic companies are stepping in to fill the void. These include “peptide companies,” manufacturers that create non-FDA approved knockoff versions of the drugs. From November 2023 to March 2024, my team carried out a study to assess which of these peptide companies are selling semaglutide or tirzepatide products. We scoured the internet looking for these peptide companies and collected information about what they were selling and their sales practices. We found that peptide sellers use a loophole to sell these drugs. On their websites, the companies state that their drugs are for “research purposes only” or “not for human consumption,” but they do nothing to verify that the buyers are researchers or that the product is going to a research facility. By reading the comments sections of the company websites and the targeted ads on social media, it becomes clear that both buyers and sellers understand the charade. Unlike compounding pharmacies, these peptide sellers do not provide the supplies you need to dissolve and inject the drug, provide no instructions, and will usually not answer questions. Peptide sellers, since they allegedly are not selling to consumers, do not require a valid prescription and will sell consumers whatever quantity of drug they wish to purchase. Even if a person has an eating disorder such as anorexia nervosa, the companies will happily sell them a semaglutide or tirzepatide product without a prescription. The average prices of these peptide products range from $181-$203 per month. Skirting regulations Peptide sellers do not have to adhere to the rules or regulations that drug manufacturers or compounding pharmacies do. Many companies state that their products are 99% pure, but an independent investigation of three companies’ products from August 2023 to March 2024 found that the purity of the products were far less than promised. One product contained endotoxin – a toxic substance produced by bacteria – suggesting that it was contaminated with microbes. In addition, the products’ promised dosages were off by up 29% to 39%. Poor purity can cause patients to experience fever, chills, nausea, skin irritation, infections and low blood pressure. In this study, some companies never even shipped the drug, telling the buyers they needed to pay an additional fee to have the product clear customs. If a consumer is harmed by a poor-quality product, it would be difficult to sue the seller, since the products specifically say they are “not for human consumption.” Ultimately, consumers are being led to spend money on products that may never arrive, could cause an infection, might not have the correct dose, and contain no instructions on how to safely use or store the product. Dr. C. Michael White is an expert in the areas of comparative effectiveness and preventing adverse events from drugs, devices, dietary supplements, and illicit substances. Dr. White is available to speak with media -- click on his icon now to arrange an interview today.

In the aftermath of last week's school shooting in Georgia, Jennifer Necci Dineen and Kerri M. Raissian from UConn’s ARMS Center contributed this compelling piece to The Atlanta Journal-Constitution. The entirety of the article is available here: On Sept. 4, the United States experienced its 45th school shooting of 2024, this time at Apalachee High School in Winder, Georgia. Barrow County Sheriff Jud Smith called the shooting “pure evil” and reported the suspected shooter would be tried as an adult. Since then, the shooter’s father has also been charged. A criminal justice response is vital, but it cannot be our only response. Gun laws need an overhaul. The failure to do so means that we will continue charging shooters and their families and attending the funerals of those senselessly killed. Laws are the role of government. Should elected officials fail to act (again), we think it is also fair to hold them responsible for the firearm violence killing our nation’s children. Georgia lawmakers have passed legislation to protect children in other ways. Georgia requires that children be at least 16 years old and to have held a learner’s permit for a year before they can drive: minors under 16 cannot be employed in dangerous or harmful jobs; and those under 17 cannot marry. These restrictions recognize that children’s prefrontal cortex, the part of their brain responsible for reasoning, impulse control and decision-making, is not yet fully formed. Yet, despite firearms being the leading cause of death for children in the United States, Georgia has minimal regulations governing children’s firearm access. There is no minimum age for purchasing or possessing rifles or shotguns, no permit required for carrying firearms in public (whether open or concealed) and no mandate for secure firearm storage (such as unloading, locking and storing ammunition separately). Details of the shooting in Winder continue to emerge, but let’s start with what we know. Reports indicate that the shooter and his father were questioned by the Jackson County Sheriff’s Office in May 2023 following multiple anonymous tips about online threats, including images of guns. The suspect’s father claimed that his child did not have unfettered access to the guns. The authorities did not have probable cause for an arrest, and so they left and the guns stayed. And, in fact, the father bought his son a new gun — an AR-15 — as a Christmas present. Perhaps more disturbing is that this kind of negligence and indifference is not an anomaly. A similar set of facts surround the Nashville Waffle House shooter and the Michigan Oxford High School Shooter. In both cases, parents ignored warning signs and helped their sons keep or procure firearms that were used in mass shootings. Moreover, almost three-quarters of guns used in gun-related incidents at schools come from the home or someone the shooter knows. It’s fair to ask: Where are the parents? However, we also want to know where are the elected officials charged with keeping us and our children safe when they are at school, the movies, a parade or otherwise living their lives? Laws mandating secure firearm storage, permitting, minimum age requirements and background checks have been proven to lower firearm homicide rates. Emergency risk protection orders, or red-flag laws, which temporarily prevent individuals deemed a danger to themselves or others from possessing or purchasing firearms, have also been effective in reducing firearm homicides. Georgia’s failure to implement such regulations, allowing a child with underdeveloped decision-making skills to access a gun, means the state shares the blame for the gun-related injuries and deaths at Apalachee High School. Georgia Gov. Brian Kemp is right. It’s not the time to “talk about safety and policy.” The time was years ago, but it’s never too late to do the right thing. Kerri Raissian is an associate professor in the School of Public Policy at the University of Connecticut; director of the University of Connecticut's UConn’s Center for Advancing Research, Methods, and Scholarship (ARMS) in Gun Violence Prevention; and co-director of the Institute for Collaboration on Health, Intervention, and Policy (InCHIP) Gun Violence Prevention Research Interest Group. Her research focuses on child and family policy, with an emphasis on understanding how policies affect fertility, family formation, and family violence. She is available to speak to media about this important topic - simply click on her icon now to arrange an interview today.

It's being called a "once in a lifetime" opportunity - and Monday's solar eclipse has almost everybody on the continent talking as well as planning and preparing to get a glimpse of this rare astronomical moment. Amid the excitement is a need for people to view the event safely, which is why NBC Connecticut recently caught up with UConn Associate Professor of Physics Jonathan Trump to explain what's happening and, if you're going to be gazing upwards, what you need to know and how to do it without getting hurt. An astronomical celebration is just around the corner. But if you want to see the solar eclipse for yourself, there are steps you need to take to do so safely. First and foremost: to watch this out-of-this-world display April 8, don’t even think about looking right at the sun. “Most important thing, do not look directly at the solar eclipse with your eyes,” said UConn associate professor of physics Jonathan Trump. “Here in Connecticut the eclipse will be about 90% which is pretty spectacular, but even 10% of the sun’s light is a lot of the sun’s light.” UConn is one of many organizations around the state holding a celebration and viewing event. “The next one is not going to be for another 20 years, so yeah this is a special event,” said Trump. Sunglasses aren’t strong enough to protect your retinas from these UV rays. “The ultraviolet light is what give us sunburns and it can severely damage the retina in the back of your eye and permanently scar your vision. So do not look directly at the sun,” said Trump. You can view the solar eclipse safely with certified solar eclipse glasses. If you wear eyeglasses, put the solar eclipse glasses on top of your glasses. And if you have solar eclipse glasses from the last phenomena visible stateside, which was seven years ago, you should get a new pair. Experts we spoke to say they have no more than a three-year shelf life.  Looking to know more?  Jonathan Trump is an observational astronomer and is available to speak with reporters about Monday's eclipse. Simply click on his icon now to arrange a time to talk today.

Guns have been identified as the leading cause of death for children in the United States, making ongoing discussions about firearm safety especially important. Kerri Raissian, an associate professor of public policy at the University of Connecticut, and Jennifer Necci Dineen, associate director of the ARMS Center for Gun Injury Prevention, recently co-authored an very important piece for The Conversation titled detailing what families need to know about safely storing firearms at home.  There were 2,571 children age 1 to 17 who died in shootings in the U.S. in 2021, 68% more than the 1,531 that occurred in 2000. To help reduce the number of firearm-related deaths and injuries among children, Secretary of Education Miguel Cardona in January 2024 called upon school and district administrators to talk with parents and guardians about safe firearm storage practices. As experts on the safe storage of firearms – and as leaders of the University of Connecticut’s ARMS Center for Gun Injury Prevention – we often get questions about the best ways to keep guns out of the hands of children. We offer the following tips: 1: Safely store all of your firearms 2. Don’t assume you can hide your guns 3. Store ammunition separately 4. Learn to talk about firearm safety 5. Know the law 6. Invest in a quality safe and/or locking device The full piece is available here from The Conversation. Kerri Raissian is an associate professor in the School of Public Policy at the University of Connecticut, director of the University of Connecticut's UConn’s Center for Advancing Research, Methods, and Scholarship (ARMS) in Gun Violence Prevention, and co-director of the Institute for Collaboration on Health, Intervention, and Policy (InCHIP) Gun Violence Prevention Research Interest Group. Her research focuses on child and family policy, with an emphasis on understanding how policies affect fertility, family formation, and family violence. She is available to speak to media about this important topic - simply click on her icon now to arrange an interview today.

Since 2022, the U.S. Food and Drug Administration has been actively urging consumers to avoid purchasing or consuming tianeptine -- a synthetic drug commonly called "gas station heroin" that can mimic the actions of opioids like fentanyl. Now, the FDA is upping the urgency of it's warnings as vendors continue to market the drug as a so-called "dietary supplement." UConn's C. Michael White, a Distinguished Professor of Pharmacy Practice, spoke with The Conversation about the problem with tianeptine in a must-read Q-and-A: What is tianeptine and why is it risky? Tianeptine stimulates the same receptors as well-known opioids such as fentanyl, heroin and morphine. When these drugs make their way from the blood to the brain, they bind to the “mu” type opioid receptor that triggers the sought-after pain relief and euphoria of those drugs as well as the dangerous effects like slowed or stopped breathing. High doses of tianeptine can bring euphoric effects similar to heroin and can also bring about the dissociative effect – the perception of your mind being disconnected from your surroundings and body – that is reminiscent of ketamine, an anesthetic that has a role in treating post-traumatic stress disorder and depression but has also commonly been abused as a street drug. Products containing tianeptine are often called “legal high drugs” – sometimes dubbed “gas station drugs” – a term used for all non-FDA-approved synthetic drugs that are sold casually in gas stations, online and elsewhere. What are the major adverse effects that people can experience? Data from clinical trials, case reports and poison control centers shows that tianeptine commonly induces agitation. This is typically accompanied by a fast heart rate and high blood pressure, confusion, nightmares, drowsiness, dry mouth and nausea, among other conditions. The most serious adverse events are slowed or stopped breathing, coma, heart arrhythmia and death. When long-term users try to stop tianeptine use, they often experience withdrawal symptoms reminiscent of opioid withdrawal. Consumers need to be aware that products containing tianeptine may not adhere to good manufacturing practices. This means they could contain lead or have other heavy metal contamination or be contaminated by microorganisms such as salmonella or mold. They could also contain other drug ingredients that are not disclosed. Knowingly or unknowingly combining active ingredients can increase the risk of adverse events. Additionally, the amount of the active ingredient contained in the product can vary widely, even with the same manufacturer. So past use does not guarantee that using the same amount will provide the same effect. How are these drugs sold in the US if they are not FDA-approved? If a drug product is not FDA-approved for prescription or over-the-counter-use, it is the Drug Enforcement Agency that is responsible for controlling market access. Before the DEA can ban an active ingredient in a drug product, it must be designated Schedule I, meaning the drug has no legitimate medical purpose and has high abuse potential. Manufacturers do not have to alert the DEA before selling their products to U.S. citizens. This means the DEA must detect an issue, identify the products causing the issue, identify the active ingredients in the product in question and do a full scientific review before designating it as Schedule I. Tianeptine came to market masquerading as a dietary supplement in gas stations and smoke shops, even though it is a synthetic compound. Tianeptine is also sold online allegedly for research purposes and not for human consumption. Tianeptine is undergoing clinical trials for the treatment of pain and depression, but sellers do nothing to make this type of labeling clear to consumers or to restrict purchases to researchers. What can people do to protect themselves and their families? Non-FDA-approved products containing synthetic drugs are very risky to use and should be avoided. FDA-approved drugs are available by a prescription from a health professional or over the counter with active ingredients on an approved list. If someone in a gas station, smoke shop or over the internet touts the benefits of a non-FDA-approved drug product – for pain or anxiety relief, to increase energy or for a buzz – be aware. It could be dangerous the first time you use it, but using it successfully once also doesn’t mean the experience will be the same the next time, and continued use can cause addiction. If a product is being sold “not for human consumption” or “for research purposes only,” you are at a high risk if you take it. Before you take any dietary supplement, make sure you check the active ingredient to be sure that it is, in fact, a natural product and not a synthetic chemical. If someone you know has bags with unmarked powder, a product labeled for research use or not for human consumption, or tablets or capsules not in standard drug bottles, that is a sign of a potentially dangerous situation. Standard drug tests sold over the counter are not designed to pick up tianeptine. One of the main reasons that people use these alternative substances of abuse over regular opioids, cannabis or amphetamines is that they are much harder to detect through work- or at-home drug screens by parents, schools, employers, probation officers and so on. If the DEA is not responding to emerging threats quickly enough, individual states can also act to ban sales of dangerous active ingredients in products. As of January 2024, at least 12 states have banned the sale of tianeptine, according to the FDA, although people in those states can still illegally procure it from the internet. So contacting your state legislators could be a place to start exercising your power to help prevent the harms from these products. This is an important piece, and if you are looking to know about tianeptine and the threat it poses to consumers in America, then let us help. Dr. C. Michael White is an expert in the areas of comparative effectiveness and preventing adverse events from drugs, devices, dietary supplements, and illicit substances. Dr. White is available to speak with media -- click on his icon now to arrange an interview today.

It's coming this summer -- and it'll be twice as big! Two broods of cicadas are set to emerge this year, an event that last occurred more than 200 years ago and now has scientists, bug watchers, and fans of the loud and noisy (yet harmless) insects buzzing with anticipation. Media coverage of this popular event put on by nature is also starting, and John R. Cooley, a cicada expert at UConn, offered his expertise on the impending emergence to MassLive: This summer, some will get a chance to witness a phenomenon rarer — and probably louder — than Halley’s comet. For the first time in more than two centuries, two big groups of cicadas in the United States will emerge simultaneously from the ground. Cicadas, often called “heat bugs,” make their presence known throughout the country every summer by “singing” their loud song. But some of these large, flying insects only emerge from underground every so often, depending on their group, or brood. These “periodical” cicadas bury themselves in soil, where they spend most of their lives. This summer, millions of cicadas from broods XIX (emerging every 13 years) and XIII (every 17 years) will both crawl out from underground and fly across the south and Midwest looking for a mate, according to Cicadamania, a website dedicated to tracking the insects. The last time these two broods popped out of the ground at the same time was in 1803, Cicadamania reported – when the U.S. bought the Louisiana Territory from France. “You cannot possibly be unaware that periodical cicadas are out, because they’re out by the millions and millions, and they’re noisy, charismatic, active insects that are just everywhere,” John R. Cooley, an entomologist who studies cicadas at the University of Connecticut, told MassLive. “When you got them, you know it. And that’s what you can expect to see. That’s what any normal emergence looks like,” he continued. What folks will see are a whole lot of bugs that all look the same, as the ones that come out every decade-plus look the same as the ones that come out every year, Cooley said. Researchers are still exploring why some cicadas emerge periodically. One common theory is that their infrequent appearance helps them avoid predators and prevents enemies from synchronizing on their life cycle. But, Cooley said this theory is flawed since all cicadas have predators, but fewer than 10 species are periodical. Some of the cicada’s natural enemies include birds, moles and Cicada killer wasps, according to the University of California Integrated Pest Management Program. Another theory suggests the last ice age forced cicadas to evolve to have longer periodical life cycles. But, that theory is limited as many cicadas live near glacial areas – few of which are periodical, according to nature.com. “Science isn’t all about having the explanations,” Cooley said. “We just test hypotheses and there are a lot of hypotheses as to why these cicadas are the way they are, but none really stand up so far.” The emerging of cicadas is always a popular and trending topic, and if you have questions or are looking to cover, then let us help. John R. Cooley is an Associate Professor in Residence at the University of Connecticut. He is an entomologist, author, and leading authority when it comes to cicadas. Simply click on his icon now to arrange a time to talk today.