Lab Notes

Medical Student Studies Brain Network Changes in Epilepsy

For people with epilepsy, a seizure can occur without warning, causing sudden loss of consciousness and a dangerous convulsion. Medications can prevent seizures for some patients, but more than a third of patients continue to have attacks despite using appropriate seizure medications. Researchers in the UConn Department of Neurology have begun to investigate how brain networks differ between people who have epilepsy and those who don’t.

Skin cells grown into nanofiber scaffold.

Bioengineers Test Better Way to Heal Chronic Wounds

'The dressing we developed enhances wound healing and prevents infections simultaneously'

UConn Expert Member of Global Commission Calling on World to Improve Sickle Cell Disease Care

Global mortality from sickle cell disease may be nearly 11 times higher than recorded, says new Commission of world experts published in The Lancet Haematology journal.

MRI or magnetic resonance image of head and brain scan.

Shorter Telomeres Point to Increased Alzheimer’s Risk

If longer telomeres actually reduce Alzheimer's risk, it’s one more reason for people to adopt a healthy lifestyle

Two men smile at the camera as the one on the right loads a cartridge full of samples into a large piece of laboratory machinery.

Microscopy on Ice with UConn Health’s New Cryogenic Equipment

Cryogenic electron microscopy, which can produce 3D pictures of minute quantities of biological material, is a new forefront of research capabilities at UConn School of Medicine

Three sections of optic nerve that were injured by crushing (the white diamond on the far left of each nerve marks the crush point.) The lower two nerves each express genes (Dynlt1a or Lars2) newly identified by the Trakhtenberg lab as promoting nerve axon regeneration. The axons carry the bright green dye. The insets to the right show how much more axon regrowth is occurring in the nerves that express the regeneration genes, and how no regrowth happens in the normal control (top).

New Nerve Insights Could Someday Help Heal Certain Types of Blindness and Paralysis

New research answers some of the big questions of how our nervous systems develop

Image of a leg in a cast

Healing Big Broken Bones With a Small Molecule

UConn Health scientists describe a new method that can promote regrowth of long bones more affordably and with fewer side effects than other techniques

Student, mental health and depression with anxiety, burnout and sad for exam results, fail or mistake while sitting outdoor. Young man, stress and tired and depressed on university or college campus.

Report: Mental Health Crises Spike Among Youth

Suicide related emergency room visits for young people have increased every year since 2011

Load it up. Column (a) shows how the high dose, slow release microneedle antibody patch (MA) works. PLGA is a biodegradable polymer that can be tuned to degrade faster or slower. The middle image shows microneedles made of differently tuned PLGA represented by different colors. The graph on the bottom shows how the patch keeps blood levels of antibodies (Ab) in a certain range, with little spikes as the different PLGA microneedles dissolve and release their antibodies into the bloodstream over 30 days. Column (b) shows the high dose powder-filling method the team developed. It can deliver doses of 4 to 5mg of antibodies per square centimeter of patch. The traditional technology shown in column (c) can deliver only much lower doses.

Less Painful, More Convenient Antibody Treatments

A timed-release patch made of biodegradable polymer could make antibody treatments more accessible and safer

An older man covers his face with his hands in a sign of severe depression.

Depressed, and Aging Fast

UConn Center on Aging researchers have found that older adults suffering from depression age faster than their peers