Lab Notes

“Chia-Ling Kuo et al. demonstrate the Healthspan Proteomic Score (HPS), derived from chronological age and the expression levels of 86 proteins, is a strong predictor of disease and mortality risk. Lower HPS values are associated with higher risks of disease and mortality. Pictured is a “biological clock” representation hinting that proteins inform the HPS, which can inform our healthspan. Here, the clock’s hand is a 3D rendering of growth/differentiation factor 15 (GDF15), a protein predictor of healthspan. Image credit: Bernard L. Cook III, PhD, who conceptualized, illustrated, and composed the final image, and Illustrate, the software used to render GDF15 (Goodsell DS, Autin L, Olson AJ (2019) Illustrate: Software for Biomolecular Illustration. Structure 27, 1716-1720).”

Scientists Develop New Blood-Based Proteomic Score to Predict Healthspan and Disease Risk

UConn School of Medicine study published in PNAS introduces Healthspan Proteomic Score as a biomarker for healthy aging

Hip fracture in older adult (AdobeStock Image).

Supervised Exercise Improves Broken Hip Outcomes in Older Women

JAMA Network Open Publishes Study Results of the STEP-HI Clinical Trial, Finding That Testosterone Gel Use in Women Recovering from Hip Fracture Does Not Improve Outcomes Compared to Supervised Exercise Alone

AdobeStock image of Alzheimer's disease patient brain scans.

UConn Uncovers New Clue on What is Leading to Neurodegenerative Diseases Like Alzheimer’s and ALS

Decreased levels of TDP-43 gene inside the nucleus of endothelial cells is disrupting blood-brain barrier’s protection

Dr. Se-Jin Lee and Dr. Emily Germain-Lee in the lab at UConn School of Medicine.

Next Generation of Weight Loss Drugs Being Researched at UConn

Nearly 30 years later Dr. Se-Jin Lee’s discovery of myostatin is not only leading to treatment for spinal muscular atrophy but also fueling the global obesity drug research race

UConn Neuroscientist Dr. Eric S. Levine in his lab at UConn School of Medicine (Photo by Lauren Woods).

Eagles Autism Foundation Awards Research Funding to UConn School of Medicine

Cutting-edge autism research of UConn Neuroscientist Dr. Eric Levine and his Lab wins $400,000 in research funds thanks to football fans donating to the annual Eagles Autism Challenge

Bacteria in between red blood cells

Sepsis, or Death By Lethal Message

If scientists understand what causes this deadly cellular message chain, they might be able to stop it

UConn Health's Cell and Genome Sciences building

Some Senescent Cells Heal, Others Hinder

In a new study, UConn School of Medicine researchers describe how to distinguish between senescent cells that speed wound healing and those that hinder it

MRI or magnetic resonance image of head and brain scan.

New Approach Could Help Alzheimer’s Research

Clues that a different than expected type of cell is involved in the earliest stages of the disease

Images show two optic nerves

Nerve Regrowth in Sight

The findings could lead to a potential treatment for a common cause of blindness

AdobeStock

UConn Researchers Working to Extinguish ‘Inflammatory Fire’ Stroke Causes in the Brain

World Stroke Day is on October 29 but all-year-round UConn is on a steadfast mission to find a new, future stroke treatment